Overview:
A synthetic analog of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid peptide involved in actin sequestration and cytoskeletal dynamics. TB-500 represents the active region of Tβ4 responsible for its primary biological interactions. It has been the subject of published preclinical research examining its role in tissue repair signaling, cell migration, and inflammatory modulation.
Research areas include:
- Actin-binding (G-actin sequestration) and cytoskeletal reorganization
- Cell migration and wound closure signaling via Rho/ROCK pathway
- Angiogenesis and endothelial cell proliferation models
- Extracellular matrix remodeling and fibroblast activity
- Inflammatory cytokine modulation (TNF-α, IL-1β, IL-6)
- Cardiac tissue repair and cardiomyocyte survival models
- Neuronal regeneration and central nervous system repair research
Compound Specifications
| Property | Value |
|---|---|
| CAS# | 77591-33-4 |
| Formula | C₂₁₂H₃₅₀N₅₆O₇₈S |
| Molecular Weight | 4963.5 g/mol |
| Class | Synthetic Thymosin Beta-4 fragment |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% HPLC |
| Storage | -20°C, protect from light |
| Reconstitution | Bacteriostatic water |
